Abstract | BACKGROUND: MATERIAL AND METHODS: We studied the efficacy of losartan (50 mg once daily for 12 weeks) on albuminuria, peripheral and autonomic neuropathy in 25 normotensive microalbuminuric type 2 diabetics who were asymptomatic for neuropathy. RESULTS: Mean age was 46.6 +/- 4.34 years with the average duration of diabetes being 8.1 +/- 1.54 years. Albuminuria improved significantly from 54 +/- 9.35 mg/L to 32.8 +/- 25 mg/L (Paired student's t-test, P=0.0005) after therapy. Autonomic neuropathy was observed in 64% while 76% had peripheral neuropathy; but there was no improvement with losartan. The duration of diabetes had a negative correlation with autonomic neuropathy. It also had a similar negative correlation with median and common peroneal nerve motor conduction velocities (Pearson's correlation coefficient, r = -0.53, P<0.01 and r = -0.56, P<0.01 respectively) implying that autonomic and peripheral neuropathy worsen as a diabetic ages. However, no correlation existed between albuminuria and autonomic or peripheral nerve function. CONCLUSION:
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Authors | S Kubba, S K Agarwal, A Prakash, V Puri, R Babbar, S Anuradha |
Journal | Neurology India
(Neurol India)
Vol. 51
Issue 3
Pg. 355-8
(Sep 2003)
ISSN: 0028-3886 [Print] India |
PMID | 14652437
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antihypertensive Agents
- Losartan
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Topics |
- Adult
- Albuminuria
(drug therapy)
- Antihypertensive Agents
(administration & dosage)
- Autonomic Nervous System Diseases
(drug therapy)
- Diabetes Mellitus, Type 2
(complications)
- Diabetic Nephropathies
(drug therapy)
- Diabetic Neuropathies
(drug therapy)
- Female
- Humans
- Losartan
(administration & dosage)
- Male
- Middle Aged
- Treatment Outcome
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