Abstract | BACKGROUND AND AIM: METHODS AND RESULTS: Levels of soluble cell adhesion molecules sICAM-1, sE- selectin and sP- selectin, PAI-1 Ag (by Elisa test), orosomucoid (ORM) and transferrin (TRF) (by microturbidimetry) and fibrinogen (FBG) according to Clauss were examined in peripheral blood of overweight adults (n 33, body mass index 27.1 +/- 1.8 kg/m2) with combined hyperlipidemia and in equal numbers of age, sex and BMI matched non-hyperlipidemic group. Overweight adults with combined hyperlipidemia had significantly higher plasma levels of sICAM-1 (376.5 +/- 107.4 ng/mL vs 239.3 +/- 60.4 ng/mL; p < 0.001), sE- selectin (70.4 +/- 20.2 ng/mL vs 48.5 +/- 25.6 ng/mL; p = 0.005), sP- selectin (228.2 +/- 88.6 ng/mL vs 123.1 +/- 45.3 ng/mL; p < 0.001) and positive acute phase proteins ORM (0.82 +/- 0.16 g/L vs 0.64 +/- 0.20 g/L; p = 0.005), FBG (3.42 +/- 0.54 g/L vs 2.74 +/- 0.57 g/L; p = 0.037) and PAI-1 Ag (97.9 +/- 40.6 ng/mL vs 56.4 +/- 25.6 ng/mL; p < 0.05), and a decrease of negative acute phase protein TRF (2.14 +/- 0.40 g/L vs 2.77 +/- 0.45 g/L; p < 0.001) compared to the results in overweight non-hyperlipidemic controls. CONCLUSIONS: It is suggested that overweight adults have an increase of inflammatory response dependent on hyperlipidemia. It was apparent from the elevation of sE-- selectin, sP-- selectin and sICAM-1 and from an increase of systemic inflammatory response according to the increase of "positive" acute phase proteins (APRs) and the decrease of "negative" APR protein levels in these patients.
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Authors | T Kvasnicka, J Kvasnicka, R Ceska, M Vrablik |
Journal | Nutrition, metabolism, and cardiovascular diseases : NMCD
(Nutr Metab Cardiovasc Dis)
Vol. 13
Issue 4
Pg. 227-31
(Aug 2003)
ISSN: 0939-4753 [Print] Netherlands |
PMID | 14650355
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acute-Phase Proteins
- Cell Adhesion Molecules
- Cholesterol, HDL
- Cholesterol, LDL
- E-Selectin
- P-Selectin
- Triglycerides
- Intercellular Adhesion Molecule-1
- Cholesterol
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Topics |
- Acute-Phase Proteins
(metabolism)
- Case-Control Studies
- Cell Adhesion Molecules
(blood)
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- E-Selectin
(blood)
- Female
- Humans
- Hyperlipidemias
(blood, complications)
- Inflammation
(blood)
- Intercellular Adhesion Molecule-1
(blood)
- Male
- Middle Aged
- Obesity
(blood, complications)
- P-Selectin
(blood)
- Triglycerides
(blood)
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