[Study of antiarrhythmic activity and duration of action of quaternidine].

Abstract

The results of experiments on dogs showed that quaternidine, a quaternary ammonium derivative of trimecaine, produces a significant antiarrhythmogenic effect in cases of rhythm disorders in the late stage of a model myocardial infarction. For drugs administered in a single isotoxic dose, the therapeutic effect of quaternidine in animals with acute myocardial ischemia considerably exceeds the duration of action of lidocaine and trimecaine.

• Authors: I Ia Moiseeva, D S Blinov, Ia V Kostin
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2003 Sep-Oct Vol. 66 Issue 5 Pg. 22-4 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Issledovanie protivoaritmicheskoĭ activnosti i prodolzhitel'nosti deĭstviia kvaternidina.
• PMID: 14650209 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Quaternary Ammonium Compounds
• quaternidine
• Trimecaine
• Quinidine

Topics

• Animals
• Anti-Arrhythmia Agents (therapeutic use)
• Disease Models, Animal
• Dogs
• Electrocardiography
• Female
• Heart Rate (drug effects)
• Male
• Quaternary Ammonium Compounds (therapeutic use)
• Quinidine (therapeutic use)
• Trimecaine (analogs & derivatives, therapeutic use)
• Ventricular Premature Complexes (drug therapy, physiopathology)