In contrast to traditional
therapy (beta-adrenoblocker and
nitrates),
energostim improves the systolic and diastolic functions of myocardium during 120-min occlusion of the left descending coronary artery. The
energostim-induced improvement in the central hemodynamics is correlated with an adaptive increase in activity of the
antioxidant system
enzymes in response to the ischemic production of
reactive oxygen species, which is evidence of the mobilization of reserves of the enzymatic link in the
antioxidant defense system of cardiomyocytes. Analogous pattern is observed in the blood. In the control group of traditional
therapy, a decrease in the
superoxide dismutase (SOD) activity and the redox potential (
NAD/
NADH) in myocardium are correlated with a decrease in the maximum rate of pressure increase in the left ventricle (R 6.4, p < 0.01) observed 2 h after the
coronary occlusion. In the
energostim treated group, there is a correlation between the SOD activity and the content of
cytochrome C in mitochondria (R 6.1, p < 0.01): a change in the level of
cytochrome C during 2-h acute
ischemia is correlated with the decrease in redox potential (
NAD/
NADH) and in the ratio of
glutathione peroxidase to Mn-dependent SOD (r 0.64, p < 0.01). Thus, disturbances in the
antioxidant defense system of both myocardium and blood plasma of the patients with acute myocardium
infarction are correlated with inability of the energy supply system to utilize
oxygen in the process of glycolysis and oxidative phosphorylation in mitochondria. Stable adaptive increase in activity of the
antioxidant defense system
enzymes and a decrease in the content of
cytochrome C in the blood plasma are probably the independent indications of beneficial prognosis and high efficacy of the proposed treatment of the ischemic damage of myocardium.