[An experimental study of the effects of profenofos on antioxidase in rabbits].

Abstract

In order to explore the effects of superoxide dismutase(SOD), catalase(CAT), glutathione-peroxidase (GSH-Px) in rabbits exposed by profenofos and its meaning. 18 rabbits were divided into three groups randomly: A group (high-dose group), B group(low-dose group), C group(control group), each group including 6 rabbits. The activities of SOD, CAT, GSH-Px in plasma, and cholinesterase(ChE) in blood were measured in different exposure period. The results showed that activities of SOD, CAT and GSH-Px increased, ChE decreased markedly compared with those in the same group before experiment and control group (P < 0.05, P < 0.01). The increase of antioxidase activities was earlier than the decease of ChE activity. It suggests that profenofos can result in the increases of the activities of SOD, CAT and GSH-Px, which may be earlier diagnostic index in profenofos poisoning.

• Authors: Li Lin, Jun Liu, Kai Zhang, Yanjun Chen
• Journal: Wei sheng yan jiu = Journal of hygiene research (Wei Sheng Yan Jiu) Vol. 32 Issue 5 Pg. 434-5 (Sep 2003) ISSN: 1000-8020 [Print] China
• PMID: 14650183 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Insecticides
• Organothiophosphates
• profenofos
• Oxidoreductases
• Catalase
• Glutathione Peroxidase
• Superoxide Dismutase

Topics

• Animals
• Catalase (metabolism)
• Female
• Glutathione Peroxidase (metabolism)
• Insecticides (toxicity)
• Lipid Peroxidation (drug effects)
• Male
• Organothiophosphates (toxicity)
• Oxidoreductases (blood)
• Rabbits
• Random Allocation
• Superoxide Dismutase (metabolism)