Effects of dietary fat on cholesterol movement between tissues in CBA/J and C57BR/cdJ mice.

Abstract

Differences in dietary fats cause differences in cholesterol metabolism in mice. CBA/J mice are resistant to diet-induced hypercholesterolemia and atherosclerosis; they adjust hepatic hydroxymethyl-glutaryl-CoA reductase activity (HMGR) to maintain homeostasis; C57BR/cdJ mice are susceptible, but young animals are thought to maintain homeostasis by changing fecal excretion of sterols. Compartmental modelling of movement of [4-14C]cholesterol was used to analyze movement of cholesterol between serum and liver, heart, and carcass in mice fed 40 en% fat, polyunsaturated to saturated fatty acid ratio (P/S) = 0.24 (US74) or 30 en% fat, P/S = 1 (MOD). Dietary effects were quite pronounced, while strain effects were more subdued. The C57/cdJ animals appear to regulate the overall cholesterol balance by reducing synthesis, as do the CBA/J animals, even though synthesis is not reduced to the same degree as in the CBA/J animals. Both diet and strain influence the whole-animal turnover rate, with slower turnover occurring for C57BR/cdJ animals and animals fed the US74 diet.

• Authors: S I Kuan, J Stewart, M K Dowd, L Patterson, J Dupont, R C Seagrave
• Journal: Journal of lipid research (J Lipid Res) Vol. 33 Issue 11 Pg. 1619-28 (Nov 1992) ISSN: 0022-2275 [Print] United States
• PMID: 1464745 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dietary Fats
• Cholesterol

Topics

• Animals
• Cholesterol (metabolism)
• Dietary Fats (administration & dosage)
• Kinetics
• Male
• Mice
• Mice, Inbred CBA
• Mice, Inbred Strains
• Models, Biological
• Organ Size
• Species Specificity
• Tissue Distribution