Sensitization profiles of Malaysian and Singaporean subjects to allergens from Dermatophagoides pteronyssinus and Blomia tropicalis.

Abstract

BACKGROUND:

The house dust mites Dermatophagoides pteronyssinus (Der p) and Blomia tropicalis (Blo t) are the most common house dust mite species in Southeast Asia. To date, there have only been a few studies on the sensitization profile of the general populations in Southeast Asia to house dust mites. The aim of this study was to determine the profiles of Der p and Blo t sensitization among Singaporean and Malaysian subjects.

METHODS:

Enzyme-linked immunosorbent assay was used to detect specific IgE to Der p and Blo t mite crude extracts as well as purified Der p 1, Der p 2 and Blo t 5 allergens. Sera used were from 229 Singaporean subjects (124 with rhinitis, 105 without rhinitis) and 143 Malaysian subjects (94 adults and 49 children with asthma).

RESULTS:

The sensitization profile of rhinitis subjects to the dust mite allergens used in this study was as follows: Blo t extract positive: 91/124 (73%); Blo t 5 positive: 62/124 (50%); Der p extract positive: 61/124 (49%); Der p 1 positive: 53/124 (43%); Der p 2 positive: 45/124 (36%). The nonrhinitis subjects' sensitization profile was as follows: Blo t extract positive: 60/105 (57%); Blo t 5 positive: 24/105 (23%); Der p extract positive: 38/105 (36%); Der p 1 positive: 14/105 (13%); Der p 2 positive: 17/105 (16%). The study of Malaysian asthmatic adults showed that 39% of them were sensitized to Der p 1, 32% to Der p 2 and 37% to Blo t 5. Among the asthmatic children, sensitization to Blo t 5, Der p 1 and Der p 2 was 90, 57 and 39%, respectively.

CONCLUSION:

This study clearly revealed that dual sensitization to B. tropicalis and D. pteronyssinus is common in the general populations of Singapore and Malaysia. Sensitization to Blo t 5 is more prevalent than to Der p 1 and Der p 2.

• Authors: S M Yeoh, I C Kuo, D Y Wang, C K Liam, C K Sam, J A De Bruyne, B W Lee, N Cheong, K Y Chua
• Journal: International archives of allergy and immunology (Int Arch Allergy Immunol) Vol. 132 Issue 3 Pg. 215-20 (Nov 2003) ISSN: 1018-2438 [Print] Switzerland
• PMID: 14646382 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2003 S. Karger AG, Basel

Chemical References

• Allergens
• Antigens, Dermatophagoides
• Antigens, Plant
• Arthropod Proteins
• Dermatophagoides pteronyssinus antigen p 2
• allergen Blo t 5
• Immunoglobulin E
• Cysteine Endopeptidases
• Dermatophagoides pteronyssinus antigen p 1

Topics

• Adolescent
• Adult
• Aged
• Allergens (immunology)
• Antigens, Dermatophagoides (immunology)
• Antigens, Plant
• Arthropod Proteins
• Asthma (immunology)
• Child
• Cysteine Endopeptidases
• Female
• Humans
• Immunoglobulin E (blood)
• Malaysia
• Male
• Middle Aged
• Rhinitis (immunology)
• Singapore