Abstract | UNLABELLED: MATERIAL AND METHODS: The safety and immunogenicity of a heptavalent pneumococcal polysaccharide conjugate vaccine ( PREVENAR was tested in French infants immunized with the 2, 3 and 4 month French schedule as part of an open, randomized, comparative clinical study, in association with a whole-cell pertussis-based pediatric combination vaccine. RESULTS: In the PREVENAR plus DTP-IPV/Hib association group, 90.6-100% of children achieved a post-dose three threshold IgG concentration of >0.15 microg/ml against each of the seven pneumococcal serotypes. Regarding immunogenicity, no interference with the antibody response to the various antigenic components of the DTP-IPV/Hib vaccine was observed. Local reactions were significantly less frequent at the PREVENAR injection site than at the DTP-IPV/Hib injection site; there was no increase in systemic adverse events in the vaccine association group compared to the DTP-IPV/Hib alone group, further exception of fever >38 degrees C which was more frequently reported in the PREVENAR + PENTACOQ group following the second dose of vaccines (56% vs. 35%); no serious adverse event could be considered to be related to the PREVENAR immunization in this study. CONCLUSION:
|
Authors | P Reinert, M Guy, B Girier, B Szelechowski, B Baudoin, P Deberdt, A Wollner, G Kemeny, M Amzallag, C Moat, C Szelechowski, H Villain-Lemoine, C-A Bouhanna, F Laudat |
Journal | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
(Arch Pediatr)
Vol. 10
Issue 12
Pg. 1048-55
(Dec 2003)
ISSN: 0929-693X [Print] France |
Vernacular Title | Tolérance et immunogénicité d'un vaccin pneumococcique osidique conjugué heptavalent (Prevenar) administré en association avec une combinaison vaccinale pédiatrique (DTCoq-Polio/Hib) à des nourrissons selon le schéma vaccinal français à l'âge de deux, trois et quatre mois. |
PMID | 14643532
(Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Diphtheria-Tetanus-Pertussis Vaccine
- Haemophilus Vaccines
- Heptavalent Pneumococcal Conjugate Vaccine
- Immunoglobulin G
- Meningococcal Vaccines
- Pneumococcal Vaccines
- Vaccines, Conjugate
- diphtheria-tetanus-pertussis-haemophilus b conjugate vaccine
|
Topics |
- Diphtheria-Tetanus-Pertussis Vaccine
(administration & dosage)
- Female
- Haemophilus Vaccines
(administration & dosage)
- Heptavalent Pneumococcal Conjugate Vaccine
- Humans
- Immunization Schedule
- Immunoglobulin G
(analysis)
- Infant
- Male
- Meningococcal Vaccines
(administration & dosage, adverse effects, immunology)
- Pneumococcal Infections
(prevention & control)
- Pneumococcal Vaccines
(administration & dosage, adverse effects, immunology)
- Vaccines, Conjugate
|