Abstract | BACKGROUND: METHODS: 32 patients (24 males and 8 females, mean (SE) age = 67 +/- 6 years) with type 2 diabetes and ischemic cardiomyopathy were randomized to receive either trimetazidine (20 mg, t.d.s.) or placebo (t.d.s.) for six months in a randomized parallel study. Patients performed an echocardiogram at baseline and after 6 months. RESULTS: Demographic data were comparable between the two groups. After six month baseline left ventricular end-diastolic diameters increased from 62.4 +/- 1.7 to 63 +/- 2.1 mm in the placebo group, while decreased from 63.2 +/- 2.1 to 58 +/- 1.6 mm (p < 0.01 compared to baseline) in the trimetazidine group. Compared to baseline, left ventricular ejection fraction increased by 5.4 +/- 0.5% (p < 0.05) in the trimetazidine group while remained unchanged in the placebo group -2.4 +/- 1.1% (NS), p < 0.01 between groups. A significant improvement in wall motion score index and in the E/A wave ratio was detected in patients treated with trimetazidine, but not in those receiving placebo. CONCLUSION:
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Authors | Giuseppe M C Rosano, Cristiana Vitale, Barbara Sposato, Giuseppe Mercuro, Massimo Fini |
Journal | Cardiovascular diabetology
(Cardiovasc Diabetol)
Vol. 2
Pg. 16
(Nov 28 2003)
ISSN: 1475-2840 [Electronic] England |
PMID | 14641923
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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