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Synthesis and cardiovascular activity of phenylalkylamine derivatives. I. Potential specific bradycardic agents.

Abstract
A series of acyclic amide derivatives of N-(omega-aminoalkyl)-N-methylhomoveratrylamine was synthesized and evaluated for their bradycardic activity in isolated guinea pig right atria. Among these compounds, (E)-N-[3-[N'-[2-(3,4-dimethoxyphenyl)ethyl]-N'-methylamino]propyl]- 4-[3,4-(methylenedioxy)phenyl]-3-butenamide (35) was the most potent in vitro and was also found to show dose-dependent bradycardia without remarkable reduction of left ventricular dp/dtmax or mean aortic pressure in anesthetized dogs.
AuthorsF Ozaki, M Matsukura, Y Kabasawa, K Ishibashi, M Ikemori, S Hamano, N Minami
JournalChemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 40 Issue 10 Pg. 2735-40 (Oct 1992) ISSN: 0009-2363 [Print] Japan
PMID1464103 (Publication Type: Journal Article)
Chemical References
  • Cardiotonic Agents
  • Verapamil
Topics
  • Animals
  • Bradycardia (chemically induced)
  • Cardiotonic Agents (chemical synthesis, pharmacology)
  • Dogs
  • Female
  • Guinea Pigs
  • Male
  • Verapamil (analogs & derivatives, chemical synthesis, pharmacology)

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