Abstract |
A series of acyclic amide derivatives of N-(omega-aminoalkyl)-N-methylhomoveratrylamine was synthesized and evaluated for their bradycardic activity in isolated guinea pig right atria. Among these compounds, (E)-N-[3-[N'-[2-(3,4-dimethoxyphenyl)ethyl]-N'-methylamino]propyl]- 4-[3,4-(methylenedioxy)phenyl]-3- butenamide (35) was the most potent in vitro and was also found to show dose-dependent bradycardia without remarkable reduction of left ventricular dp/dtmax or mean aortic pressure in anesthetized dogs.
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Authors | F Ozaki, M Matsukura, Y Kabasawa, K Ishibashi, M Ikemori, S Hamano, N Minami |
Journal | Chemical & pharmaceutical bulletin
(Chem Pharm Bull (Tokyo))
Vol. 40
Issue 10
Pg. 2735-40
(Oct 1992)
ISSN: 0009-2363 [Print] Japan |
PMID | 1464103
(Publication Type: Journal Article)
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Chemical References |
- Cardiotonic Agents
- Verapamil
|
Topics |
- Animals
- Bradycardia
(chemically induced)
- Cardiotonic Agents
(chemical synthesis, pharmacology)
- Dogs
- Female
- Guinea Pigs
- Male
- Verapamil
(analogs & derivatives, chemical synthesis, pharmacology)
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