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New developments in the pharmacotherapy of tension-type headaches.

Abstract
The first International Headache Society classification defined tension-type headaches (TTHs) by itemising those characteristics of migraines TTHs did not possess [1]. As a result, TTHs, both episodic and chronic, remain the most nonspecific of all the commonly observed primary headaches. Until recently, there has been little impetus on the part of the pharmaceutical industry to investigate TTHs; many of the potentially useful drugs are now generic and unprofitable. In addition, few investigators have pursued the study of TTHs in lieu of its more glamorous neighbour, migraine. As a result, there are few well-designed studies on the pharmacotherapy of TTHs. The few studies that exist support the use of age-old standard drug classes, the tricyclic antidepressants and the NSAIDs. New research is now emerging that points to the potential utility of botulinum toxin type A, NMDA-receptor antagonists including Mg(2+) and nitric oxide synthase inhibitors. More scientifically rigorous clinical studies are needed.
AuthorsChonghao Zhao, Mark J Stillman
JournalExpert opinion on pharmacotherapy (Expert Opin Pharmacother) Vol. 4 Issue 12 Pg. 2229-37 (Dec 2003) ISSN: 1465-6566 [Print] England
PMID14640922 (Publication Type: Comparative Study, Journal Article, Review)
Chemical References
  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antidepressive Agents
  • Neuromuscular Agents
  • Receptors, N-Methyl-D-Aspartate
  • Nitric Oxide Synthase
  • Botulinum Toxins
  • Magnesium
Topics
  • Analgesics (therapeutic use)
  • Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
  • Antidepressive Agents (therapeutic use)
  • Botulinum Toxins (therapeutic use)
  • Clinical Trials as Topic
  • Humans
  • Magnesium (therapeutic use)
  • Neuromuscular Agents (therapeutic use)
  • Nitric Oxide Synthase (antagonists & inhibitors)
  • Receptors, N-Methyl-D-Aspartate (antagonists & inhibitors)
  • Tension-Type Headache (drug therapy, epidemiology, prevention & control)

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