Constituents of the Vietnamese medicinal plant Streptocaulon juventas and their antiproliferative activity against the human HT-1080 fibrosarcoma cell line.

Abstract

The methanolic extract of roots of Streptocaulon juventas, having shown strong antiproliferative activity against the highly metastatic human HT-1080 fibrosarcoma cell line, was subjected to activity-guided isolation to yield 16 cardenolides including five new ones, acovenosigenin A 3-O-beta-digitoxopyranoside (1), digitoxigenin gentiobioside (2), digitoxigenin 3-O-[O-beta-glucopyranosyl-(1-->6)-O-beta-glucopyranosyl-(1-->4)-3-O-acetyl-beta-digitoxopyranoside] (3), digitoxigenin 3-O-[O-beta-glucopyranosyl-(1-->6)-O-beta-glucopyranosyl-(1-->4)-O-beta-digitalopyranosyl-(1-->4)-beta-cymaropyranoside] (4), and periplogenin 3-O-(4-O-beta-glucopyranosyl-beta-digitalopyranoside) (5), and two new hemiterpenoids, (4R)-4-hydroxy-3-isopropylpentyl beta-rutinoside (6) and (R)-2-ethyl-3-methylbutyl beta-rutinoside (7), together with two known phenylpropanoids and a known phenylethanoid. The isolated cardenolides strongly inhibited the proliferation of the HT-1080 cell line (IC(50) values, 54-1600 nM).

• Authors: Jun-Ya Ueda, Yasuhiro Tezuka, Arjun H Banskota, Quan Le Tran, Qui Kim Tran, Ikuo Saiki, Shigetoshi Kadota
• Journal: Journal of natural products (J Nat Prod) Vol. 66 Issue 11 Pg. 1427-33 (Nov 2003) ISSN: 0163-3864 [Print] United States
• PMID: 14640513 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cardenolides

Topics

• Cardenolides (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Esterification
• Fibrosarcoma
• Humans
• Hydrolysis
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Plants, Medicinal (chemistry)
• Stereoisomerism
• Tumor Cells, Cultured (drug effects)
• Vietnam