Subthalamic somatosensory evoked potentials in Parkinson's disease.

Deep brain stimulation (DBS) of subthalamic nucleus (STN) is an effective treatment for advanced Parkinson's disease. It also provides an opportunity to record neural activity from the human basal ganglia. In this study, to investigate the involvement of the human STN in sensory functions, we recorded somatosensory evoked potentials (SEPs) elicited by contralateral median-nerve stimulation, from STN electrodes implanted for DBS in patients with Parkinson's disease. We suggest that the STN N18 component of SEPs in Parkinson's disease is a mainly local field potential elicited by muscle afferent input to the nucleus.
AuthorsAlessandra Pesenti, Alberto Priori, Marco Locatelli, Marcello Egidi, Paolo Rampini, Filippo Tamma, Elena Caputo, Valentina Chiesa, Sergio Barbieri
JournalMovement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 18 Issue 11 Pg. 1341-5 (Nov 2003) ISSN: 0885-3185 [Print] United States
PMID14639678 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
  • Adult
  • Aged
  • Electric Stimulation (instrumentation)
  • Electrodes, Implanted
  • Evoked Potentials, Somatosensory (physiology)
  • Female
  • Humans
  • Male
  • Median Nerve (physiology)
  • Middle Aged
  • Muscle, Skeletal (innervation)
  • Parkinson Disease (physiopathology)
  • Subthalamic Nucleus (physiopathology)

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