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Do thiazide diuretics confer specific protection against strokes?

Abstract
Several large studies have suggested that therapy with thiazide diuretics confers a particular benefit in reducing the risk of strokes that seem to be, at least to some extent, independent of the blood pressure-lowering effect. Such a cerebroprotective effect was documented not only with monotherapy but also when diuretics were used in combination with other drugs. The cerebroprotective effect does not seem to be shared by other drug classes, such as the beta-blockers or the angiotensin-converting enzyme inhibitors, in patients without manifest cardiovascular disease. Since stroke is one of the most devastating sequelae of high blood pressure, our data strongly favor the use of low-dose diuretics either as initial therapy or in combination in all hypertensive patients at risk for cerebrovascular disease.
AuthorsFranz H Messerli, Ehud Grossman, Anthony F Lever
JournalArchives of internal medicine (Arch Intern Med) Vol. 163 Issue 21 Pg. 2557-60 (Nov 24 2003) ISSN: 0003-9926 [Print] United States
PMID14638555 (Publication Type: Journal Article, Review)
Chemical References
  • Antihypertensive Agents
  • Benzothiadiazines
  • Diuretics
  • Sodium Chloride Symporter Inhibitors
Topics
  • Antihypertensive Agents (pharmacology, therapeutic use)
  • Benzothiadiazines
  • Blood Pressure (drug effects)
  • Comorbidity
  • Diuretics
  • Drug Therapy, Combination
  • Humans
  • Hypertension (drug therapy, epidemiology)
  • Renin-Angiotensin System (drug effects, physiology)
  • Sodium Chloride Symporter Inhibitors (pharmacology, therapeutic use)
  • Stroke (epidemiology, physiopathology, prevention & control)

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