Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in trans.

Abstract

We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.

• Authors: Fátima Lasala, Eva Arce, Joaquín R Otero, Javier Rojo, Rafael Delgado
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 47 Issue 12 Pg. 3970-2 (Dec 2003) ISSN: 0066-4804 [Print] United States
• PMID: 14638512 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• BH30sucMan
• Cell Adhesion Molecules
• DC-specific ICAM-3 grabbing nonintegrin
• Lectins, C-Type
• Mannans
• Receptors, Cell Surface
• Viral Envelope Proteins

Topics

• Antiviral Agents (chemical synthesis, pharmacology)
• Cell Adhesion Molecules (drug effects)
• Cells, Cultured
• Dose-Response Relationship, Drug
• Drug Design
• Ebolavirus (drug effects, growth & development)
• Hemorrhagic Fever, Ebola (drug therapy, virology)
• Humans
• Lectins, C-Type (drug effects)
• Lentivirus (genetics)
• Mannans (chemical synthesis, pharmacology)
• Receptors, Cell Surface (drug effects)
• Stereoisomerism
• Vesicular stomatitis Indiana virus (drug effects, growth & development)
• Viral Envelope Proteins (chemistry, drug effects)