Abstract | OBJECTIVES: To verify the cut-off values and to determine the clinical sensitivity of antithyroglobulin (TgAb) determinations using our routine RIA and the new electrochemiluminescent Elecsys assay. DESIGN AND METHODS: RESULTS: As expected, using the proposed thresholds (BRAHMS 60 kIU/L, Elecsys 115 kIU/L) approximately 6% of the control subjects were positive for TgAb with both methods. In AITD patients, the sensitivity of TgAb determination was significantly higher with the Elecsys assay (51.5%) than with the BRAHMS assay (39.3%). This difference was not observed in the other patient groups. CONCLUSION: The Elecsys assay can be preferred not only because it is automated and rapid, but also because of its better clinical performance in AITD patients.
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Authors | Rémy Sapin, Michèle d'Herbomez, Françoise Gasser, Laurent Meyer, Jean-Louis Schlienger |
Journal | Clinical biochemistry
(Clin Biochem)
Vol. 36
Issue 8
Pg. 611-6
(Nov 2003)
ISSN: 0009-9120 [Print] United States |
PMID | 14636875
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- anti-thyroglobulin
- Thyroglobulin
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Topics |
- Adult
- Autoantibodies
(blood)
- Electrochemistry
- Female
- Graves Disease
(blood, immunology)
- Humans
- Immunoassay
(methods)
- Luminescent Measurements
- Male
- Middle Aged
- Sensitivity and Specificity
- Thyroglobulin
(blood, immunology)
- Thyroiditis, Autoimmune
(immunology)
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