Effects of nefiracetam, DM-9384 on amnesia and decrease in choline acetyltransferase activity induced by cycloheximide.

Abstract

The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

• Authors: T Shiotani, K Tohyama, K Murase, S Ishihara, T Kameyama, T Yamasaki, S Hatanaka, H Kojima, Y Takasu, T Nabeshima
• Journal: Journal of neural transmission. General section (J Neural Transm Gen Sect) Vol. 90 Issue 2 Pg. 103-11 ( 1992) Austria
• PMID: 1463591 (Publication Type: Journal Article)

Chemical References

• Psychotropic Drugs
• Pyrrolidinones
• nefiracetam
• Cycloheximide
• Choline O-Acetyltransferase

Topics

• Amnesia (chemically induced, enzymology, physiopathology)
• Animals
• Avoidance Learning (drug effects)
• Brain (enzymology)
• Choline O-Acetyltransferase (antagonists & inhibitors)
• Cycloheximide (pharmacology)
• Male
• Mice
• Psychotropic Drugs (pharmacology)
• Pyrrolidinones (pharmacology)