In vitro antigiardial activity of IRE-6A and IRE-7B, two ethyl-phenylcarbamate derivatives.

Abstract

Resistance is a practical problem associated to the use of benzimidazoles in the antigiardial therapy. Since benzimidazole-resistant strains of fungi have shown increased sensitivity to phenylcarbamates, in this study we synthesized and in vitro tested novel substituted phenylcarbamates against the protozoa Giardia intestinalis. IRE-6A and IRE-7B, two 4-R-ethyl-phenylcarbamates demonstrated an important antigiardial activity although that was modest when compared to albendazole in axenic cultures of Giardia intestinalis. Results of this study suggest a potential role of phenylcarbamates as alternative to benzimidazoles in the therapy of giardiasis.

• Authors: Enedina Jiménez-Cardoso, Andrés Flores-Luna, E Angeles, P Martínez, R López-Castañares, G Castañeda-Hernández, José Pérez-Urizar
• Journal: Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion (Rev Invest Clin) 2003 Jul-Aug Vol. 55 Issue 4 Pg. 444-7 ISSN: 0034-8376 [Print] Mexico
• PMID: 14635610 (Publication Type: Journal Article)

Chemical References

• Antiprotozoal Agents
• Carbamates
• IRE-6A
• IRE-7B
• Albendazole

Topics

• Albendazole (pharmacology)
• Animals
• Antiprotozoal Agents (pharmacology)
• Carbamates (pharmacology)
• Giardia lamblia (drug effects)