Abstract | BACKGROUND/AIMS: METHODS: Sera were collected from 25 patients with IBD (17 with CD, 8 with UC) and 32 healthy controls. The levels of pANCA and ASCA were determined by using a standard indirect immunofluorescence technique on ethanol-fixed granulocytes and an ELISA assay, respectively. RESULTS: In patients with UC, the sensitivity, specificity, and positive predictive value of the pANCA test were 38%, 88%, and 60%, respectively. Such values were not changed significantly in the case of positive pANCA and negative ASCA. The sensitivity, specificity, and positive predictive value of ASCA test in diagnosing CD were 71%, 88%, and 92%, respectively. The combination of pANCA negative and ASCA positive was not significant. CONCLUSIONS: ASCA and pANCA assays are highly disease specific for CD and UC, respectively. These serological tests can assist clinicians in diagnosing and categorizing patients with IBD and may be useful in making therapeutic decisions.
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Authors | Jeong Eun Kim, Kyo Sun Kim, Jeong Kee Seo |
Journal | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
(Korean J Gastroenterol)
Vol. 42
Issue 4
Pg. 297-302
(Oct 2003)
ISSN: 1598-9992 [Print] Korea (South) |
PMID | 14634349
(Publication Type: Journal Article)
|
Chemical References |
- Antibodies, Antineutrophil Cytoplasmic
- Antibodies, Fungal
- Mannans
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Topics |
- Adolescent
- Antibodies, Antineutrophil Cytoplasmic
(analysis)
- Antibodies, Fungal
(analysis)
- Child
- Child, Preschool
- Colitis, Ulcerative
(diagnosis)
- Crohn Disease
(diagnosis)
- Enzyme-Linked Immunosorbent Assay
- Female
- Fluorescent Antibody Technique
- Humans
- Male
- Mannans
(immunology)
- Predictive Value of Tests
- Saccharomyces cerevisiae
(immunology)
- Sensitivity and Specificity
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