Abstract | BACKGROUND: OBJECTIVES: To investigate in vivo the PpIX fluorescence time course after topical application of ALA in order to determine the optimal time for irradiation, and to assess the efficacy of subsequently performed ALA- PDT. METHODS: Fluorescence kinetics was studied in 12 male patients with condylomata acuminata. Confirmation of diagnosis was established with conventional histology and polymerase chain reaction. Lesions were treated with 20% ALA and irradiated at the optimal time with a dose of 70 J cm-2 or 100 J cm-2 light. An additional session with 100 J cm-2 was administered 1 week later to lesions that persisted. RESULTS: The in vivo study of fluorescence kinetics indicated that the optimal time for irradiation varied among patients from 6 to 11 h. The overall cure rate was 72.9%, 12 months after treatment. CONCLUSIONS:
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Authors | I M Stefanaki, S Georgiou, G C Themelis, E M Vazgiouraki, A D Tosca |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 149
Issue 5
Pg. 972-6
(Nov 2003)
ISSN: 0007-0963 [Print] England |
PMID | 14632801
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Photosensitizing Agents
- Protoporphyrins
- Aminolevulinic Acid
- protoporphyrin IX
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Topics |
- Adult
- Aminolevulinic Acid
(therapeutic use)
- Condylomata Acuminata
(drug therapy, metabolism)
- Fluorescence
- Humans
- Male
- Penile Diseases
(drug therapy, metabolism)
- Photochemotherapy
(methods)
- Photosensitizing Agents
(administration & dosage, pharmacokinetics)
- Protoporphyrins
(administration & dosage, pharmacokinetics)
- Time Factors
- Treatment Outcome
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