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Ethacrynic acid can be effective for refractory congestive heart failure and ascites.

Abstract
Ethacrynic acid is a loop diuretic little used today because of its side-effect profile and the availability of multiple alternative agents. However, in our clinical experience, ethacrynic acid can alleviate acute congestive heart failure and ascites resistant to other diuretics. Two patients aged 89 and 94 in life-threatening pulmonary edema were stabilized by ethacrynic acid after furosemide proved ineffective. A third patient, aged 83, with a pleural effusion and ascites secondary to end-stage hepatitis B and C, responded to ethacrynic acid when spironolactone and furosemide produced little urine output. Ethacrynic acid may have a unique niche as a diuretic of last resort, especially in geriatric practice.
AuthorsJoseph M Alisky, Thomas F Tuttle
JournalSouthern medical journal (South Med J) Vol. 96 Issue 11 Pg. 1148-50 (Nov 2003) ISSN: 0038-4348 [Print] United States
PMID14632366 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Diuretics
  • Ethacrynic Acid
Topics
  • Aged
  • Aged, 80 and over
  • Ascites (drug therapy)
  • Diuretics (therapeutic use)
  • Ethacrynic Acid (therapeutic use)
  • Female
  • Heart Failure (drug therapy)
  • Humans
  • Male
  • Treatment Outcome

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