Abstract |
RISK OF INFECTION IN SPLENECTOMIZED CHILDREN: Observations in cohorts of splenectomized patients have led to the conclusion that the risk of bacterial infection is highest among young children, particularly under the age of 2 years, within 2 years of splenectomy and in children with an associated disease. SEVERITY OF THE INFECTIONS: According to the Holdsworth study conducted between 1952 and 1987, the rate of postoperative infection in splenectomized children under the age of 16 years is 4.4%, mortality reaching 2.2%. The risk of severe bacterial infection is also high in sickle-cell anemia children and is the leading cause of death in this age group. BASIS FOR ANTIBIOTIC PROPHYLAXIS: GUIDELINES:
Antibiotic prophylaxis against infection in asplenic and hyposplenic children is based on daily administration of Oracilline (Penicilline V). Prophylaxis is started at diagnosis in sickle-cell anemia children, i.e. around 2-3 months of age in case of neonatal screening. Oracilline should be given at least 5 years after splenectomy or even longer, and up to the age of 15 years in sickle-cell anemia children who develop frequent ENT/bronchial complications or have a history of pneumococcal infection.
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Authors | M de Montalembert |
Journal | Presse medicale (Paris, France : 1983)
(Presse Med)
Vol. 32
Issue 28 Suppl
Pg. S15-6
(Sep 06 2003)
ISSN: 0755-4982 [Print] France |
Vernacular Title | Antibioprophylaxie des infections bactériennes chez l'enfant hyposplénique ou asplénique. |
PMID | 14631640
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Penicillin V
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Topics |
- Adolescent
- Age Factors
- Anemia, Sickle Cell
(complications, drug therapy)
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Antibiotic Prophylaxis
- Bacterial Infections
(etiology, prevention & control)
- Child
- Child, Preschool
- Humans
- Infant, Newborn
- Penicillin V
(administration & dosage, therapeutic use)
- Practice Guidelines as Topic
- Risk Factors
- Splenectomy
(adverse effects)
- Time Factors
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