| Abstract | A 2-year-old boy with severe multiorgan disease (i.e., otitis, enteritis, bilateral pneumonia, encephalopathy, myocarditis, rash) was diagnosed with adenovirus-associated macrophage activation syndrome according to clinical and laboratory parameters (fever, hepatosplenomegaly, bicytopenia, hyperferritinemia, hypertriglyceridemia). He had no unusual history of earlier infections or a family history of hemophagocytic syndrome or immune defects. Intravenous immunoglobulin was administered to prevent exacerbation of the suspected incipient hemophagocytic syndrome. Clarithromycin, a macrolide with immunomodulatory effect, was included in the antibiotic regimen of the progressive pneumonia, followed by rapid amelioration and remission of clinical and laboratory findings. Causal links between treatment and clinical improvement are discussed and a brief review of the recent literature is included. |
| Authors | Markus G Seidel, Ulrike Kastner, Milen Minkov, Helmut Gadner
(Affiliation: St. Anna Children's Hospital, Children Cancer Research Institute CCRI, Kinderspitalgasse 6, A-1090 Vienna, Austria.)
|
| Journal | Pediatric hematology and oncology
(Pediatr Hematol Oncol)
Vol. 20
Issue 6
Pg. 445-51
(Sep 2003)
ISSN: 0888-0018 England |
| PMID | 14631618
(Publication Type: Case Reports, Journal Article, Review)
|
| Chemical References |
- Immunoglobulins, Intravenous
- Ferritins
|
| Topics |
- Adenovirus Infections, Human
(complications)
- Child, Preschool
- Ferritins
(blood)
- Hepatomegaly
(etiology)
- Histiocytosis, Non-Langerhans-Cell
(diagnosis, etiology, therapy)
- Humans
- Immunoglobulins, Intravenous
(therapeutic use)
- Macrophage Activation
- Male
- Splenomegaly
(etiology)
|
