[A leukotriene antagonist (montelukast) in the treatment of atopic dermatitis in pediatric patients].

Abstract

BACKGROUND:

Leukotrienes participate in certain biological activities such as contraction of human airway muscle, increased vascular permeability, chemotaxis and allergen-induced early and late responses.

OBJECTIVE:

To evaluate the leukotriene antagonist montelukast in patients with atopic dermatitis unresponsive to traditional treatment.

METHODS:

Eighteen children with atopic dermatitis were treated with 5 mg of chewable montelukast every 24 hs during a period of 24 weeks. Patient's history was utilized as a control for each individual. On each visit, every child was assessed by a single observer and objectively scored for disease extent and severity. In addition every parent filled a similar evaluation.

RESULTS:

There was statistical improvement (p < 0.01) when values before and after treatment were analyzed, although no improvement was reported in five. No adverse reactions were reported.

CONCLUSION:

Findings suggest that leukotriene antagonists can be used as an adjunct treatment on patients with atopic dermatitis that are refractory to traditional management.

• Authors: Luz Elena Concha del Río, Carlos M Arroyave
• Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) (Rev Alerg Mex) 2003 Sep-Oct Vol. 50 Issue 5 Pg. 187-91 ISSN: 0002-5151 [Print] Mexico
• Vernacular Title: Antagonista de un leucotrieno (montelukast) en el tratamiento de dermatitis atópica en pacientes pediátricos.
• PMID: 14631590 (Publication Type: Journal Article)

Chemical References

• Acetates
• Cyclopropanes
• Leukotriene Antagonists
• Quinolines
• Sulfides
• montelukast

Topics

• Acetates (administration & dosage, therapeutic use)
• Administration, Oral
• Adolescent
• Child
• Child, Preschool
• Cyclopropanes
• Dermatitis, Atopic (drug therapy)
• Drug Evaluation
• Female
• Humans
• Leukotriene Antagonists (administration & dosage, therapeutic use)
• Male
• Quinolines (administration & dosage, therapeutic use)
• Sulfides
• Treatment Outcome