Aromatase expression in low-grade endometrial stromal sarcomas: an immunohistochemical study.

Abstract

Aromatase expression has been described in stromal cells of endometriosis, adenomyosis and endometrial cancer. We analyzed aromatase expression in a series of 23 low-grade endometrial stromal sarcomas. Archival formalin-fixed and paraffin-embedded material was analyzed with immunohistochemistry. Aromatase expression was evaluated with a monoclonal and a polyclonal antibody using the peroxidase-antiperoxidase method. A score was calculated based on the percentage of positive tumor cells and the staining intensity. Aromatase was seen in 19 (83%) of 23 tumors with monoclonal antibody and 20 (87%) of 23 tumors with polyclonal antibody. Aromatase expression using the monoclonal antibody was scored as high in five (22%), moderate in nine (39%) and low in five (22%) tumors. Four (17%) low-grade endometrial stromal sarcomas did not stain for aromatase. Aromatase expression with the polyclonal antibody was scored as high in seven (31%), moderate in four (17%) and low in nine (39%) tumors. Three (13%) low-grade endometrial stromal sarcomas did not stain for aromatase. Little or no aromatase expression tended to correlate with stage I disease, while higher scores were more frequently associated with advanced disease. Our results demonstrate that most low-grade endometrial stromal sarcomas express aromatase. The staining pattern, however, is heterogeneous. The high percentage of aromatase positivity in low-grade endometrial stromal sarcomas may have implications in the management of these tumors and offer new treatment modalities such as hormonal therapy with aromatase inhibitors.

• Authors: Olaf Reich, Sigrid Regauer
• Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (Mod Pathol) Vol. 17 Issue 1 Pg. 104-8 (Jan 2004) ISSN: 0893-3952 [Print] United States
• PMID: 14631363 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antineoplastic Agents, Hormonal
• Aromatase Inhibitors
• Aromatase

Topics

• Adult
• Aged
• Antibodies, Monoclonal
• Antineoplastic Agents, Hormonal (therapeutic use)
• Aromatase (analysis, immunology)
• Aromatase Inhibitors (therapeutic use)
• Endometrial Neoplasms (drug therapy, enzymology, pathology)
• Female
• Humans
• Immunoenzyme Techniques
• Middle Aged
• Neoplasm Staging
• Patient Selection
• Prognosis
• Sarcoma, Endometrial Stromal (drug therapy, enzymology, pathology)