Synthesis and anti-measles virus activity of new isoquinolin-4-one derivatives.

Abstract

Despite intense efforts to increase vaccine coverage, measles virus (MV) still causes significant morbidity and mortality in the world sometimes as a results of severe, chronic and lethal diseases. In an effort to develop therapies to supplement immunization strategies a number of 1-oxo-2-[[(1E)-phenylmethylene]amino]-1,2-dihydroisoquinoline-4-carboxylic acid derivatives were synthesized and evaluated for anti-measles activity. The substituents on the aromatic ring were chosen in order to evaluate the influence of electron-withdrawing or electron-donating effects on the electronic density of the aromatic moiety. We also evaluated the introduction of a vinyl chain between the exocyclic nitrogen and phenyl moiety. The biological results allow to outline some preliminary considerations on structure-activity relationship.

• Authors: N A Santagati, E Bousquet, A Garozzo, O Prezzavento, A Spadaro, G Ronsisvalle
• Journal: Farmaco (Societa chimica italiana : 1989) (Farmaco) Vol. 58 Issue 12 Pg. 1217-25 (Dec 2003) ISSN: 0014-827X [Print] France
• PMID: 14630231 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Isoquinolines
• isoquinoline

Topics

• Antiviral Agents (chemical synthesis, pharmacology)
• Isoquinolines (chemical synthesis, pharmacology)
• Measles virus (drug effects, growth & development)
• Structure-Activity Relationship