Abstract | OBJECTIVE: METHODS: Twelve-month retrospective review of presentations to a tertiary paediatric ED (42,000 visits annually) via an ED computer database search and review of medical charts of children presenting with joint or skin reactions. Telephone interviews were conducted with the caregivers of children with cefaclor SSLR. RESULTS: Adverse skin or joint reactions occurred in 150 children; 70 after cefaclor alone, 10 after cefaclor in combination with other antibiotics and 70 after other antibiotic courses. SSLR occurred in 44 children; 32 after cefaclor alone, five after cefaclor in combination with other antibiotics and seven after other single antibiotics. In children with cefaclor SSLR, otitis media was the most common indication (59.4%), another 18.8% had viral illnesses. Prolonged sequelae occurred in four children, a situation not previously reported. Sixty reports of paediatric cefaclor SSLR were made to ADRAC during the study period, none originated from PMH ED. CONCLUSIONS:
Cefaclor was associated with 53.3% of oral antibiotic related skin and joint adverse reactions and 84.1% of SSLR. The indications for its use in paediatric illness require careful reconsideration. ADRAC data under-represents the incidence of cefaclor SSLR.
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Authors | B A King, G C Geelhoed |
Journal | Journal of paediatrics and child health
(J Paediatr Child Health)
Vol. 39
Issue 9
Pg. 677-81
(Dec 2003)
ISSN: 1440-1754 [Electronic] Australia |
PMID | 14629499
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Cefaclor
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Topics |
- Administration, Oral
- Adolescent
- Adverse Drug Reaction Reporting Systems
- Age Distribution
- Anti-Bacterial Agents
(adverse effects, therapeutic use)
- Cefaclor
(adverse effects, therapeutic use)
- Child
- Child, Preschool
- Cohort Studies
- Drug Eruptions
(diagnosis, epidemiology)
- Female
- Follow-Up Studies
- Humans
- Incidence
- Joint Diseases
(chemically induced, epidemiology)
- Male
- Recurrence
- Retrospective Studies
- Risk Assessment
- Serum Sickness
(chemically induced, epidemiology, physiopathology)
- Severity of Illness Index
- Sex Distribution
- Western Australia
(epidemiology)
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