Abstract | BACKGROUND: METHOD: Fifty-seven subjects with first-episode psychosis and a DSM-IV diagnosis of schizophreniform disorder, schizophrenia, or schizoaffective disorder were treated according to a fixed protocol with a mean dose of haloperidol of 1.68 mg/day and prospectively studied for 12 months. Subjects were assessed for extrapyramidal symptoms and psychiatric symptoms at 3-month intervals. Data were gathered from 1999 to 2001. RESULTS: Twelve-month incidence of probable or persistent tardive dyskinesia according to Schooler and Kane criteria was 12.3% (N = 7). Subjects with tardive dyskinesia did not differ from the rest of the sample regarding gender, race, duration of untreated psychosis, or baseline clinical characteristics. Subjects with tardive dyskinesia were older compared with subjects without tardive dyskinesia (37.14 +/- 9.23 vs. 27.30 +/- 8.09 years, respectively; t = -2.77, df = 30, p = .01) and received higher mean doses of haloperidol at 12 months (2.80 +/- 1.64 vs. 1.39 +/- 0.69 mg/day, respectively; t = -3.13, df = 25, p = .004). Cox regression analysis revealed that age at inclusion (p = .031), percentage change in negative symptoms (p = .028), and dose of haloperidol at 12 months (p = .016) were significant predictors of risk for tardive dyskinesia. CONCLUSION:
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Authors | Piet P Oosthuizen, Robin A Emsley, J Stephanus Maritz, Jadri A Turner, N Keyter |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 64
Issue 9
Pg. 1075-80
(Sep 2003)
ISSN: 0160-6689 [Print] United States |
PMID | 14628983
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antipsychotic Agents
- Haloperidol
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Topics |
- Adolescent
- Adult
- Antipsychotic Agents
(administration & dosage, adverse effects)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Dyskinesia, Drug-Induced
(diagnosis, etiology)
- Female
- Follow-Up Studies
- Haloperidol
(administration & dosage, adverse effects)
- Humans
- Male
- Middle Aged
- Neurologic Examination
(drug effects)
- Psychotic Disorders
(drug therapy, psychology)
- Risk Factors
- Schizophrenia
(drug therapy)
- Schizophrenic Psychology
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