The role of alpha 1-proteinase inhibitor in semisoluble glucan induced resistance to hemorrhage.

Abstract

The present study was undertaken to evaluate the mechanism of protective effect of semisoluble beta-1,3-carboxymethylglucan (CMG) during acute massive hemorrhage. CBA mice were injected i.v. with glucan (25 mg/kg) 24 h prior to hemorrhage (50% of blood circulating volume). Survival data indicated that glucan increased survival compared with control. However, alpha 1-proteinase inhibitor activity in serum have been even decreased 24 h after glucan administration. Moreover enhancement of active oxygen form production and leakage of cytosol and lysosomal enzymes after CMG application were noted.

• Authors: E I Vereschagin, T A Korolenko, S A Arkhipov
• Journal: Agents and actions. Supplements (Agents Actions Suppl) Vol. 38 ( Pt 3) Pg. 385-8 ( 1992) ISSN: 0379-0363 [Print] Switzerland
• PMID: 1462871 (Publication Type: Journal Article)

Chemical References

• Glucans
• alpha 1-Antitrypsin
• beta-Glucans
• carboxymethyl-beta-1,3-glucan
• Acid Phosphatase
• beta-Galactosidase

Topics

• Acid Phosphatase (blood)
• Animals
• Glucans (pharmacology, therapeutic use)
• Hemorrhage (blood, physiopathology)
• Lysosomes (enzymology)
• Male
• Mice
• Mice, Inbred CBA
• alpha 1-Antitrypsin (metabolism)
• beta-Galactosidase (blood)
• beta-Glucans