Effects of ursodeoxycholic acid on photodynamic therapy in a murine tumor model.

Abstract

We previously reported that the efficacy of photodynamic therapy (PDT) in cell culture was enhanced by ursodeoxycholic acid (UDCA), a nontoxic bile acid. In this study, we examined the ability of UDCA to promote tumor control by PDT in the mouse, using the radiation-induced fibrosarcoma tumor and the photosensitizing agent tin etiopurpurin (SnET2). These experiments revealed that the addition of UDCA to a PDT protocol promoted inhibition of tumor growth, a phenomenon unrelated to either altered SnET2 biodistribution or the level of vascular shutdown during irradiation. These results indicate that UDCA acts solely by promoting direct tumor cell kill by PDT.

• Authors: Greta M Garbo, M Graça Vicente, Victor Fingar, David Kessel
• Journal: Photochemistry and photobiology (Photochem Photobiol) Vol. 78 Issue 4 Pg. 407-10 (Oct 2003) ISSN: 0031-8655 [Print] United States
• PMID: 14626670 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Photosensitizing Agents
• Porphyrins
• tin etiopurpurin
• Ursodeoxycholic Acid

Topics

• Animals
• Male
• Mice
• Mice, Inbred C3H
• Models, Biological
• Neoplasms, Experimental (blood supply, drug therapy)
• Photochemotherapy
• Photosensitizing Agents (pharmacokinetics, therapeutic use)
• Porphyrins (pharmacokinetics, therapeutic use)
• Tissue Distribution
• Ursodeoxycholic Acid (pharmacology, therapeutic use)