Abstract |
Adipose tissue is not simply a store of excess energy, but also secretes a variety of proteins into circulating blood that influence systemic metabolism. These include tumor necrosis factor ( TNF-alpha), plasminogen activator inhibitor type 1 (PAI-1), leptin, resistine and adiponectin. These are collectively known as adipocytokines. Adiponectin (also referred to as AdipoQ, Acrp 30, apM1 or GBP28) is a novel adipose-specific protein. A recent genome study mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome on chromosome 3q27, where the adiponectin gene is located. Adiponectin is a peculiar adipocytokine because in contrast to the markedly increased levels of many others, as leptin or TNF-alpha, its level is reduced in obesity and type 2 diabetes. The administration of thiazolidinediones, which are synthetic PPARs-gamma ligands, significantly increases the plasma adiponectin concentrations, an effect that could improve insulin sensitivity. Thus, the administration of adiponectin may provide a novel treatment modality for insulin resistance and type 2 diabetes.
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Authors | E Lebas, N Paquot, A J Scheen |
Journal | Revue medicale de Liege
(Rev Med Liege)
Vol. 58
Issue 9
Pg. 554-8
(Sep 2003)
ISSN: 0370-629X [Print] Belgium |
Vernacular Title | L'adiponectine: une nouvelle adipocytokine. |
PMID | 14626649
(Publication Type: English Abstract, Journal Article, Review)
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Chemical References |
- Adiponectin
- Intercellular Signaling Peptides and Proteins
- Proteins
- Receptors, Cytoplasmic and Nuclear
- Thiazolidinediones
- Tumor Necrosis Factor-alpha
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Topics |
- Adiponectin
- Adipose Tissue
(physiopathology)
- Coronary Artery Disease
(physiopathology)
- Humans
- Insulin Resistance
(physiology)
- Intercellular Signaling Peptides and Proteins
- Proteins
(physiology)
- Receptors, Cytoplasmic and Nuclear
(metabolism)
- Thiazolidinediones
(metabolism)
- Tumor Necrosis Factor-alpha
(metabolism)
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