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[Adiponectin: a new adipocytokine]

AbstractAdipose tissue is not simply a store of excess energy, but also secretes a variety of proteins into circulating blood that influence systemic metabolism. These include tumor necrosis factor (TNF-alpha), plasminogen activator inhibitor type 1 (PAI-1), leptin, resistine and adiponectin. These are collectively known as adipocytokines. Adiponectin (also referred to as AdipoQ, Acrp 30, apM1 or GBP28) is a novel adipose-specific protein. A recent genome study mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome on chromosome 3q27, where the adiponectin gene is located. Adiponectin is a peculiar adipocytokine because in contrast to the markedly increased levels of many others, as leptin or TNF-alpha, its level is reduced in obesity and type 2 diabetes. The administration of thiazolidinediones, which are synthetic PPARs-gamma ligands, significantly increases the plasma adiponectin concentrations, an effect that could improve insulin sensitivity. Thus, the administration of adiponectin may provide a novel treatment modality for insulin resistance and type 2 diabetes.
AuthorsE Lebas, N Paquot, A J Scheen (Affiliation: Service de Diabétologie, Nutrition et Maladies métaboliques, Département de Médecine, CHU Sart Tilman, Liège.)
JournalRevue médicale de Liège (Rev Med Liege) Vol. 58 Issue 9 Pg. 554-8 (Sep 2003) ISSN: 0370-629X Belgium
Vernacular TitleL'adiponectine: une nouvelle adipocytokine.
PMID14626649 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Adiponectin
  • Intercellular Signaling Peptides and Proteins
  • Proteins
  • Receptors, Cytoplasmic and Nuclear
  • Thiazolidinediones
  • Tumor Necrosis Factor-alpha
Topics
  • Adiponectin
  • Adipose Tissue (physiopathology)
  • Coronary Artery Disease (physiopathology)
  • Humans
  • Insulin Resistance (physiology)
  • Intercellular Signaling Peptides and Proteins
  • Proteins (physiology)
  • Receptors, Cytoplasmic and Nuclear (metabolism)
  • Thiazolidinediones (metabolism)
  • Tumor Necrosis Factor-alpha (metabolism)