Abstract | PURPOSE: METHODS: Five adult rabbits were used. Three different combinations of drugs were injected into the epidural space, in the following order: first (combination A), 1.5 ml of 2% lidocaine; second (combination B), 1.5 ml of 2% lidocaine and 150 micro g deoxyaconitine; and third (combination C), 3 mg nor-binaltorphimine followed by 1.5 ml of 2% lidocaine and 150 micro g deoxyaconitine 30 min later. The latency of onset and the duration of three end-points (sensory loss in the tail, loss of weight-bearing ability, and flaccid paresis of hind limb) were measured. RESULTS: Onset times for the three end-points were not changed by deoxyaconitine or by nor-binaltorphimine. The duration of sensory loss was 27.0 +/- 2.7 min, the duration of loss of weight-bearing ability was 33.0 +/- 2.7 min, and the duration of flaccid paresis was 21.0 +/- 4.2 min in the combination A group. In the combination B group, deoxyaconitine extended the time of sensory loss by 80%, the time of loss of weight-bearing by 50%, and that of flaccid paresis by 60% compared with the combination A group. In the combination C group, this phenomenon was partially antagonized by pretreatment with nor-binaltorphimine, a kappa- opioid antagonist. CONCLUSIONS:
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Authors | Yasuo Komoda, Shuichi Nosaka, Makoto Takenoshita |
Journal | Journal of anesthesia
(J Anesth)
Vol. 17
Issue 4
Pg. 241-5
( 2003)
ISSN: 0913-8668 [Print] Japan |
PMID | 14625711
(Publication Type: Journal Article)
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Chemical References |
- Adjuvants, Immunologic
- Anesthetics, Local
- deoxyaconitine
- Lidocaine
- Aconitine
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Topics |
- Aconitine
(administration & dosage, analogs & derivatives, pharmacology)
- Adjuvants, Immunologic
(administration & dosage, pharmacology)
- Analysis of Variance
- Anesthesia, Epidural
(methods)
- Anesthetics, Local
(administration & dosage, therapeutic use)
- Animals
- Blood Pressure
(drug effects)
- Drug Synergism
- Female
- Lidocaine
(administration & dosage, therapeutic use)
- Paresis
- Rabbits
- Time Factors
- Weight-Bearing
(physiology)
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