Abstract | BACKGROUND: In inflammatory bowel disease (IBD), gut microvascular thrombosis as well as thromboembolic complications have repeatedly been observed. We examined the long-term course of markers of coagulation and fibrinolysis in relation to clinical disease activity. MATERIALS AND METHODS: RESULTS: Levels of F1.2, TAT, D-dimer, PAP and PAI-1 were significantly higher in active versus inactive CD and UC. However, even after 12 months of follow-up, in CD and UC the mean levels of F1.2, D-dimer and PAP were significantly higher than the levels of the controls. CONCLUSIONS: Levels of F1.2, D-dimer and PAP were markedly raised for a long time in clinically inactive IBD, underlining a chronic state of hypercoagulation and enhanced fibrinolysis.
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Authors | Anton A Vrij, Joop Rijken, Jan W J van Wersch, Reinhold W Stockbrügger |
Journal | Pathophysiology of haemostasis and thrombosis
(Pathophysiol Haemost Thromb)
2003 Mar-Apr
Vol. 33
Issue 2
Pg. 75-83
ISSN: 1424-8832 [Print] Switzerland |
PMID | 14624048
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2003 S. Karger AG, Basel |
Chemical References |
- Biomarkers
- C-Reactive Protein
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Topics |
- Adult
- Aged
- Biomarkers
(blood)
- Blood Coagulation
- Blood Sedimentation
- C-Reactive Protein
(analysis)
- Case-Control Studies
- Colitis, Ulcerative
(blood)
- Crohn Disease
(blood)
- Female
- Fibrinolysis
- Giant Cell Arteritis
(blood)
- Humans
- Inflammatory Bowel Diseases
(blood)
- Male
- Middle Aged
- Prospective Studies
- Thrombophilia
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