Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia.

Abstract

The neuroprotective effect of the neurotensin analogue H-Lys-psi(CH2NH)Lys-Pro-Tyr-Ile-Leu-OH (JMV-449) was assessed in a mouse model of permanent distal middle cerebral artery occlusion. Mice were injected with 0.6 nmol JMV-449 or vehicle i.c.v. immediately after ischaemia. The core temperature declined by 6-7 degrees C after 30 min and the hypothermia persisted for 4-5 h. JMV-449 treatment was able to reduce the infarct volume significantly both at 24 h and 14 days after onset of ischaemia. No neuroprotective effect could be seen if the mice were kept normothermic after the JMV-449 treatment suggesting that the neuroprotective effect is mediated via the hypothermia.

• Authors: Lars Torup, Jeanett Borsdal, Thomas Sager
• Journal: Neuroscience letters (Neurosci Lett) Vol. 351 Issue 3 Pg. 173-6 (Nov 20 2003) ISSN: 0304-3940 [Print] Ireland
• PMID: 14623134 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Neuroprotective Agents
• Oligopeptides
• JMV 449
• Neurotensin

Topics

• Animals
• Brain Ischemia (drug therapy, pathology)
• Disease Models, Animal
• Infarction, Middle Cerebral Artery (drug therapy, pathology)
• Male
• Mice
• Neuroprotective Agents (therapeutic use)
• Neurotensin (analogs & derivatives, therapeutic use)
• Oligopeptides (therapeutic use)