Early kidney transplantation may prevent aluminium-related bone disease.

In uraemia patients aluminium (Al) accumulation in bone leads to low turn-over bone disease. Al-related bone disease causes bone pain, non-traumatic fractures and hypercalcaemia, and does not respond to treatment with vitamin D compounds. Al-contaminated dialysate and ingestion of Al-containing phosphate binding agents are the main risk factors for bone Al accumulation. Studies of selected patients have indicated that Al-related bone disease ameliorates after successful kidney transplantation, but systematic studies of bone Al have not been reported. In a prospective study we investigated the effect of successful kidney transplantation on bone Al and clinical bone disease.
AuthorsK P Nordal, E Dahl, J Halse, A Flatmark
JournalTransplant international : official journal of the European Society for Organ Transplantation (Transpl Int) Vol. 5 Suppl 1 Pg. S98-9 ( 1992) ISSN: 0934-0874 [Print] Germany
PMID14621745 (Publication Type: Journal Article)
Chemical References
  • Adrenal Cortex Hormones
  • Immunosuppressive Agents
  • Cyclosporine
  • Creatinine
  • Aluminum
  • Adrenal Cortex Hormones (therapeutic use)
  • Aluminum (pharmacokinetics, toxicity)
  • Biopsy
  • Bone Diseases (chemically induced, prevention & control)
  • Bone and Bones (drug effects, metabolism, pathology)
  • Creatinine (blood)
  • Cyclosporine (therapeutic use)
  • Follow-Up Studies
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Kidney Transplantation (mortality, pathology, physiology)
  • Time Factors

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