Abstract | AIMS AND OBJECTIVES: MATERIAL AND METHODS: This was a randomized, double-blind, controlled, prospective study. Total 30 patients with acute MI were included. All patients were thrombolysed with streptokinase. Fifteen of these patients were randomly selected to receive esmolol while other 15 patients served as controls. The parameters compared at 0, 2 and 24 hours between the esmolol group and the controls were-- malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GPX). RESULTS: Patients with MI had 5.16 times higher MDA level at 0 hours (20.34 +/- 6.12 nmol/ml vs. 3.94 +/- 0.70 nmol/ml, p < 0.0001) than MDA level in normal healthy population. At 2 hours, patients with MI had 5.71 times higher MDA level compared to normal healthy population (22.51 +/- 5.51 nmol/ml vs. 3.94 +/- 0.70 nmol/ml, p < 0.0001). A statistically significant difference in MDA levels at 2 and 24 hours was observed in MI patients given esmolol (mean change 2.06 +/- 5.39 nmol/ml vs. -4.47 +/- 6.93 nmol/ml, p = 0.009). Esmolol infusion also caused significant difference in GPX level at 2 hours compared to controls (23.79 + 14.68 U/gm Hb vs 38.3 +/- 8.95 U/gm Hb, p = 0.003). CONCLUSION:
|
Authors | M K Daga, Madhuchanda Chaudhary, Bhavneesh Sharma, Jayshree Bhattacharjee, D S Ghambhir, N Arora, R Sudha |
Journal | The Journal of the Association of Physicians of India
(J Assoc Physicians India)
Vol. 51
Pg. 677-80
(Jul 2003)
ISSN: 0004-5772 [Print] India |
PMID | 14621036
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Adrenergic beta-Antagonists
- Antioxidants
- Free Radicals
- Oxidants
- Propanolamines
- Malondialdehyde
- Glutathione Peroxidase
- esmolol
|
Topics |
- Adrenergic beta-Antagonists
(therapeutic use)
- Adult
- Antioxidants
(therapeutic use)
- Double-Blind Method
- Female
- Free Radicals
(blood)
- Glutathione Peroxidase
(blood)
- Humans
- Male
- Malondialdehyde
(blood)
- Middle Aged
- Myocardial Infarction
(blood, drug therapy)
- Myocardial Reperfusion Injury
(prevention & control)
- Oxidants
(blood)
- Propanolamines
(therapeutic use)
- Prospective Studies
|