Abstract | BACKGROUND/AIM: METHODS: rats were divided into 4 experimental groups: The first group was given CCl4 alone; the second was given both CCl4 and captopril (100 mg x kg(-1) x day(-1)); the third was given both CCl4 and candesartan cilexetil (8 mg x kg(-1) x day(-1)); fourth group was given 0.9% NaCl only. Seven weeks after initiating the treatment, indices of fibrosis were assessed. RESULTS:
Candesartan cilexetil treatment significantly reduced the fibrosis development. These inhibitory effects were not observed in the captopril-treated group. The mean fibrosis score was significantly lower in the CCl4/ candesartan group compared with the group applied to CCl4 alone and the group applied to CCl4/ captopril. Similarly, the number of alpha-smooth muscle actin positive cells was markedly suppressed by candesartan treatment. CONCLUSIONS: The results suggest that AT-II plays a pivotal role in hepatic fibrogenesis and candesartan significantly attenuates the progression of liver fibrosis. This drug may provide an effective new strategy for prevention of liver fibrosis. Its effectiveness should be investigated in chronic liver disease associated with progressive fibrosis.
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Authors | Ilyas Tuncer, Hanefi Ozbek, Serdar Ugras, Irfan Bayram |
Journal | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
(Exp Toxicol Pathol)
Vol. 55
Issue 2-3
Pg. 159-66
(Sep 2003)
ISSN: 0940-2993 [Print] Germany |
PMID | 14620537
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Actins
- Angiotensin II Type 1 Receptor Blockers
- Angiotensin-Converting Enzyme Inhibitors
- Benzimidazoles
- Biphenyl Compounds
- Tetrazoles
- Captopril
- Carbon Tetrachloride
- candesartan
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Topics |
- Actins
(analysis)
- Angiotensin II Type 1 Receptor Blockers
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Animals
- Benzimidazoles
(therapeutic use)
- Biphenyl Compounds
- Captopril
(therapeutic use)
- Carbon Tetrachloride
(toxicity)
- Cell Count
- Disease Models, Animal
- Immunohistochemistry
- Liver
(chemistry, drug effects, pathology)
- Liver Cirrhosis, Experimental
(drug therapy, etiology)
- Male
- Rats
- Rats, Sprague-Dawley
- Tetrazoles
(therapeutic use)
- Treatment Outcome
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