[Evaluation of efficacy of 153Sm-EDTMP in patients with painful bone metastases of breast cancer].

Abstract

OBJECTIVE:

To explore the therapeutic efficacy of 153Sm-EDTMP in treating painful bone metastases from breast cancer.

METHODS:

Seventy-six patients with painful bone metastases from breast cancer entered the study and were treated by intravenous administration of 153Sm-EDTMP in two doses.

RESULTS:

Overall, 65 of 76 patients (85.52%) experienced prompt pain relief; among them 25 patients (32.89%) felt complete remission and 40 patients (52.63%) met with moderate remission. Follow-up imaging examinations were performed after each course of treatment. Complete metastatic foci disappearance was achieved in 6 cases and partial metastatic foci disappearance or regression was achieved in 16 cases, so the global effective rate was 28.95%. No major adverse effects were observed, and hematological toxicity did not exceed grade 3 in accordance to the World Health Organization criteria.

CONCLUSION:

153Sm-EDTMP is safe and effective for fast palliation of painful bone metastases and for inhibition of metastatic foci from breast cancer.

• Authors: Haiming Wu, Tianzhi Tan, Ling Fang, Xiying Zhang
• Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (Sichuan Da Xue Xue Bao Yi Xue Ban) Vol. 34 Issue 4 Pg. 716-8 (Oct 2003) ISSN: 1672-173X [Print] China
• PMID: 14619591 (Publication Type: Journal Article)

Chemical References

• Analgesics, Non-Narcotic
• Organometallic Compounds
• Organophosphorus Compounds
• samarium Sm-153 lexidronam

Topics

• Adult
• Aged
• Analgesics, Non-Narcotic (therapeutic use)
• Bone Neoplasms (radiotherapy, secondary)
• Breast Neoplasms (pathology, radiotherapy)
• Evaluation Studies as Topic
• Female
• Humans
• Injections, Intravenous
• Middle Aged
• Organometallic Compounds (therapeutic use)
• Organophosphorus Compounds (therapeutic use)
• Pain Measurement
• Pain, Intractable (drug therapy, etiology)