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The role of Jo-1 in the immunopathogenesis of polymyositis: current hypotheses.

Abstract
Polymyositis represents an autoimmune disease in which T cells mediate destruction of muscle cells. Although the precise trigger(s) for this process remain unknown, distinct clinical subsets exist that are characterized by antibodies directed against specific nuclear and cytoplasmic antigens including Jo-1 (histidyl-transfer RNA synthetase). Coupled with a range of genetic and histomorphologic data, the stereotypical serologic response suggests that antigen-specific T cells directed against Jo-1 can promote T cell-mediated cytolysis of muscle cells as well as anti-Jo-1 antibody formation in selected patients with polymyositis. Beyond a previously developed animal model that has demonstrated the capacity of Jo-1 to promote humoral and cell-mediated immune responses leading to myositis, recent studies have revealed the existence of Jo-1-specific T cells in the peripheral blood of patients with Jo-1 antibody-positive polymyositis. Even more striking, investigators have discovered that Jo-1 can serve as a chemokine for immature dendritic cells and T lymphocytes. Collectively, these findings suggest a mechanism by which Jo-1 can bridge the innate and adaptive immune responses, leading to the breakdown of tolerance and autoimmune destruction of muscle.
AuthorsDana P Ascherman
JournalCurrent rheumatology reports (Curr Rheumatol Rep) Vol. 5 Issue 6 Pg. 425-30 (Dec 2003) ISSN: 1523-3774 [Print] United States
PMID14609486 (Publication Type: Journal Article, Review)
Chemical References
  • Autoantibodies
  • Histidine-tRNA Ligase
Topics
  • Animals
  • Autoantibodies (analysis)
  • Autoimmune Diseases (immunology, physiopathology)
  • Histidine-tRNA Ligase (analysis, immunology)
  • Humans
  • Polymyositis (immunology, physiopathology)
  • Sensitivity and Specificity

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