Cerebellar ataxia and leukoencephalopathy associated with cobalamin deficiency.

Abstract

We report a patient who presented progressive cerebellar ataxia associated with vitamin B(12) deficiency. Brain magnetic resonance imaging (MRI) demonstrated a diffuse leukoencephalopathy. Six months after the initiation of methylcobalamin therapy, there were clinical improvement and reduction in the MRI abnormalities.

• Authors: Shuhei Morita, Hideto Miwa, Tameko Kihira, Tomoyoshi Kondo
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 216 Issue 1 Pg. 183-4 (Dec 15 2003) ISSN: 0022-510X [Print] Netherlands
• PMID: 14607321 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ferric Compounds
• ferric oxide
• mecobalamin
• Vitamin B 12

Topics

• Brain Stem (metabolism, pathology, physiopathology)
• Cerebellar Ataxia (etiology, metabolism, pathology)
• Cerebellum (metabolism, pathology, physiopathology)
• Cerebral Cortex (metabolism, pathology, physiopathology)
• Dementia, Vascular (etiology, metabolism, pathology)
• Female
• Ferric Compounds (therapeutic use)
• Humans
• Magnetic Resonance Imaging
• Middle Aged
• Nerve Fibers, Myelinated (metabolism, pathology)
• Recovery of Function (drug effects)
• Treatment Outcome
• Vitamin B 12 (analogs & derivatives, therapeutic use)
• Vitamin B 12 Deficiency (complications, drug therapy)