Synthesis and biological evaluation of substituted quinolines: potential treatment of protozoal and retroviral co-infections.

Abstract

We report the synthesis of substituted quinolines and their in vitro biological evaluation against the causal agents of cutaneous leishmaniasis, visceral leishmaniasis, African trypanosomiasis and Chagas' disease. Furthermore, several quinolines have also been tested for their anti-retroviral activity in HIV-1 infected cells. The structure-activity relationships of these new synthetic compounds are discussed and emphasis was placed on the treatment of leishmania/HIV co-infections.

• Authors: Mohammed A Fakhfakh, Alain Fournet, Eric Prina, Jean-François Mouscadet, Xavier Franck, Reynald Hocquemiller, Bruno Figadère
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 11 Issue 23 Pg. 5013-23 (Nov 17 2003) ISSN: 0968-0896 [Print] England
• PMID: 14604664 (Publication Type: Journal Article)

Chemical References

• Quinolines

Topics

• Animals
• Drug Evaluation, Preclinical
• Female
• HIV Infections (complications, drug therapy)
• HIV-1 (drug effects)
• Humans
• Leishmania (classification, drug effects)
• Mice
• Mice, Inbred BALB C
• Protozoan Infections (complications, drug therapy)
• Quinolines (chemical synthesis, chemistry, pharmacology, therapeutic use)
• Structure-Activity Relationship
• Trypanosoma (classification, drug effects)