Abstract |
Absolute configuration of taxiresinol 1, a lignan from the heartwood of Taxus wallichiana has been determined as 8R, 8'R, and 7'R with the help of chemical correlation method and X-ray crystallography. The anticancer activity of taxiresinol 1 and other two lignans 2, 3 were also studied. Taxiresinol 1 showed notable anticancer activity in the in vitro bioassays against colon, liver, ovarian and breast cancer cell lines.
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Authors | Sunil K Chattopadhyay, T R Santha Kumar, Prakas R Maulik, Sachin Srivastava, Ankur Garg, Ashoke Sharon, Arvind S Negi, Suman Preet S Khanuja |
Journal | Bioorganic & medicinal chemistry
(Bioorg Med Chem)
Vol. 11
Issue 23
Pg. 4945-8
(Nov 17 2003)
ISSN: 0968-0896 [Print] England |
PMID | 14604656
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Furans
- Lignans
- Plant Extracts
- taxiresinol
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Topics |
- Antineoplastic Agents, Phytogenic
(chemistry, pharmacology)
- Cell Line, Tumor
- Drug Screening Assays, Antitumor
- Furans
(chemistry, pharmacology)
- Humans
- Lignans
(chemistry, pharmacology)
- Magnetic Resonance Spectroscopy
- Molecular Structure
- Plant Extracts
(chemistry, pharmacology)
- Taxus
(chemistry)
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