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Absolute configuration and anticancer activity of taxiresinol and related lignans of Taxus wallichiana.

Abstract
Absolute configuration of taxiresinol 1, a lignan from the heartwood of Taxus wallichiana has been determined as 8R, 8'R, and 7'R with the help of chemical correlation method and X-ray crystallography. The anticancer activity of taxiresinol 1 and other two lignans 2, 3 were also studied. Taxiresinol 1 showed notable anticancer activity in the in vitro bioassays against colon, liver, ovarian and breast cancer cell lines.
AuthorsSunil K Chattopadhyay, T R Santha Kumar, Prakas R Maulik, Sachin Srivastava, Ankur Garg, Ashoke Sharon, Arvind S Negi, Suman Preet S Khanuja
JournalBioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 11 Issue 23 Pg. 4945-8 (Nov 17 2003) ISSN: 0968-0896 [Print] England
PMID14604656 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Furans
  • Lignans
  • Plant Extracts
  • taxiresinol
Topics
  • Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Furans (chemistry, pharmacology)
  • Humans
  • Lignans (chemistry, pharmacology)
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Extracts (chemistry, pharmacology)
  • Taxus (chemistry)

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