HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Therapeutic usefulness of propoxyphene napsylate in narcotic addiction.

Abstract
The maximum doses of propoxyphene napsylate used to treat heroin addicts produce a degree of morphine-like activity equal to that produced by 20 to 25 mg/day of subcutaneously given morphine or 10 mg/day orally given methadone. This degree of activity wound be sufficient to ameliorate abstinence even in patients dependent on large doses of narcotics--an observation that supports the utility of propoxyphene napsylate in detoxification. On the other hand, only patients taking 10 mg/day or less of parenterally administered heroin could be maintained on maximum subtoxic levels of propoxyphene napsylate without abstinence signs or symptoms suggesting that propoxyphene napsylate would be less useful in maintenance therapy.
AuthorsD R Jasinski, J S Pevnick, S C Clark, J D Griffith
JournalArchives of general psychiatry (Arch Gen Psychiatry) Vol. 34 Issue 2 Pg. 227-33 (Feb 1977) ISSN: 0003-990X [Print] UNITED STATES
PMID14602 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Placebos
  • Morphine
  • Dextropropoxyphene
Topics
  • Administration, Oral
  • Dextropropoxyphene (administration & dosage, adverse effects, analogs & derivatives, pharmacology, therapeutic use)
  • Dose-Response Relationship, Drug
  • Drug Evaluation
  • Heroin Dependence (rehabilitation)
  • Humans
  • Male
  • Morphine (pharmacology)
  • Morphine Dependence (drug therapy)
  • Placebos
  • Pupil (drug effects)
  • Substance Withdrawal Syndrome (prevention & control)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: