Uncinoside A and B, two new antiviral chromone glycosides from Selaginella uncinata.

Abstract

Five compounds have been isolated from the dried whole plants of Selaginella uncinata, two of them were new chromone glycosides, 5-hydroxy-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside (uncinoside A) and 5-acetoxyl-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside (uncinoside B). Their structures were elucidated by spectroscopic methods including one- and two-dimensional NMR techniques. The other three compounds were identified as 8-methyl eugenitol, amentoflavone and hinokiflavone. Uncinoside A and B showed potent antiviral activities against respiratory syncytial virus (RSV) with IC(50) value of 6.9 and 1.3 microg/ml, moderate antiviral activities against parainfluenza type 3 virus (PIV 3) with IC(50) value of 13.8 and 20.8 microg/ml, respectively.

• Authors: Ling-Yun Ma, Shuang-Cheng Ma, Feng Wei, Rui-Chao Lin, Paul Pui-Hay But, Spencer Hon-Sun Lee, Song Fong Lee
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 51 Issue 11 Pg. 1264-7 (Nov 2003) ISSN: 0009-2363 [Print] Japan
• PMID: 14600370 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 5-acetoxyl-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside
• 5-hydroxy-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside
• Antiviral Agents
• Chromones
• Plant Extracts

Topics

• Antiviral Agents (isolation & purification, pharmacology)
• Cell Survival (drug effects)
• Chromones (isolation & purification, pharmacology)
• Crystallography, X-Ray
• Cytopathogenic Effect, Viral (drug effects)
• Hydrolysis
• Magnetic Resonance Spectroscopy
• Models, Molecular
• Molecular Conformation
• Parainfluenza Virus 3, Human (drug effects)
• Plant Extracts (chemistry, pharmacology)
• Respiratory Syncytial Viruses (drug effects)
• Selaginellaceae (chemistry)
• Spectrometry, Mass, Fast Atom Bombardment
• Spectrophotometry, Infrared
• Spectrophotometry, Ultraviolet
• Virus Replication (drug effects)