Influence of HLA class II molecules on the outcome of hepatitis B virus infection in population of Zhejiang Province in China.

Abstract

OBJECTIVE:

To investigate the correlation between HLA class II molecules and the different outcome of viral hepatitis B.

METHODS:

Thirty patients with chronic hepatitis B and 56 subjects who had spontaneously recovered from HBV infection in Zhejiang were enrolled in this investigation. HLA class II molecules types and alleles were determined by PCR-ssp.

RESULTS:

HLA-DR12 was found in 21 of the 56 subjects (38%) recovered from hepatitis B, compared to 3 of the 30 patients with chronic hepatitis B [10%, relative risk (rr), 0.19; Pcorr<0.025]. The frequency of the allele of HLA-DR12 DRB1*1201 was higher in the subjects recovered from hepatitis B infection (32%) than in the patients with chronic hepatitis B (3%; rr, 0.07; Pcorr<0.005). On the contrary, more HLA-DR9 was detected in the patients with chronic hepatitis B (43%) than in the subjects who recovered from hepatitis B infection (18%; rr, 3.52; Pcorr<0.025). HLA-DQ9 was also detected with a higher frequency in the patients with chronic hepatitis B (43%) than in the subjects who recovered from hepatitis B (20%; rr, 3.13; Pcorr<0.05).

CONCLUSIONS:

The HLA class II molecule DR12 and its allele DRB1*1201 are associated with protection against chronic hepatitis B in Zhejiang Province, China. HLA-DR9 and DQ9 are associated with chronicity of HBV infection.

• Authors: Xue-Qin Meng, Hu-Guang Chen, Yi-Lin Ma, Ke-Zhou Liu
• Journal: Hepatobiliary & pancreatic diseases international : HBPD INT (Hepatobiliary Pancreat Dis Int) Vol. 2 Issue 2 Pg. 230-3 (May 2003) ISSN: 1499-3872 [Print] Singapore
• PMID: 14599975 (Publication Type: Journal Article)

Chemical References

• HLA-DQ Antigens
• HLA-DQ9 antigen
• HLA-DR Antigens
• HLA-DR Serological Subtypes
• HLA-DR12 antigen
• HLA-DR9 antigen
• HLA-DRB1 Chains
• Histocompatibility Antigens Class II

Topics

• Adult
• Alleles
• China
• Female
• HLA-DQ Antigens (genetics)
• HLA-DR Antigens (genetics)
• HLA-DR Serological Subtypes
• HLA-DRB1 Chains
• Hepatitis B, Chronic (genetics)
• Histocompatibility Antigens Class II (genetics)
• Humans
• Male
• Middle Aged
• Remission, Spontaneous