Epidemiology and clinical burden of acute myeloid leukemia.

Abstract

Acute myeloid leukemia is the most common type of leukemia in adults, yet it continues to have the lowest survival rate of all leukemias. Prognosis for the elderly in particular continues to be dismal. This review examines the currently available literature on the epidemiology, etiology, diagnosis and management of acute myeloid leukemia. New therapies and therapeutic strategies must be found to improve survival, especially as the worldwide population ages. Gemtuzumab ozogamicin (Mylotarg) for the treatment of patients with CD33-positive acute myeloid leukemia, selective FLT3 inhibitors currently in advanced development (e.g., SU11248, PKC412, CT53518 and CEP-710) and other targeted compounds (e.g., farnesyl transferase inhibitors, BCL-2 inhibitors and interleukin-2) may present initial opportunities to achieve improved outcomes.

• Authors: Alberto Redaelli, Jennifer M Lee, Jennifer M Stephens, Chris L Pashos
• Journal: Expert review of anticancer therapy (Expert Rev Anticancer Ther) Vol. 3 Issue 5 Pg. 695-710 (Oct 2003) ISSN: 1473-7140 [Print] England
• PMID: 14599092 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents

Topics

• Age Factors
• Antineoplastic Agents (therapeutic use)
• Humans
• Leukemia, Myeloid (classification, diagnosis, epidemiology, mortality, therapy)
• Prognosis
• Salvage Therapy
• Sex Factors
• Survival Rate