We have previously reported that dietary
sesamin and
sesaminol, major
lignans of sesame seed, elevate the
alpha-tocopherol concentration and decrease the
thiobarbituric acid reactive substance (
TBARS) concentration in the plasma and liver of rats. In this study, the effects of dietary
sesamin and
sesaminol on the lipid peroxidation in the plasma and tissues of rats fed
docosahexaenoic acid (DHA, 22:6 n-3) were examined. Male Wistar rats (4-wk-old) were divided into the following six experimental groups: control group, fed a basal diet:
sesamin group, fed a diet with
sesamin (2 g/kg);
sesaminol group, fed a diet with
sesaminol (2 g/kg); DHA group, fed a diet containing DHA (5 g/kg); DHA +
sesamin group, fed a diet containing DHA with
sesamin; and DHA +
sesaminol group, fed a diet containing DHA with
sesaminol. Each diet contained either 0.01 or 0.05 g
D-alpha-tocopherol/kg, and the rats were fed the respective experimental diet for 5 wk. The dietary DHA elevated the
TBARS concentration and also increased the red blood-cell
hemolysis induced by the
dialuric acid. The dietary
sesamin and
sesaminol lowered the
TBARS concentrations and decreased the red blood
hemolysis. The dietary
sesamin and
sesaminol elevated the
alpha-tocopherol concentrations in the plasma, liver, and brain of the rats fed a diet with or without DHA. These results suggest that dietary sesame
lignans decrease lipid peroxidation as a result of elevating the
alpha-tocopherol concentration in rats fed DHA.