[Successfully treated case with microscopic polyangiitis complicated severe varicella zoster virus infection including encephalitis and disseminated varicella zoster].

Abstract	We report a case with microscopic polyangiitis (MPA) complicated by varicella zoster encephalitis. A 60-year-old woman caught a common cold and had acute otitis media in April 1998. Proteinuria and hematuria with hyaline cast were noted at the routine medical check in May, and she was referred to our hospital because of high fever and chest pain. MPA was diagnosed with acute progressive renal failure, pleuritis and elevated anti-neutrophil cytoplasmic myeloperoxidase antibody (MPO-ANCA). Corticosteroid therapy was administered under hemodialysis but MPA was flared several times with various symptoms including interstitial pneumonitis, alveolar hemorrhage and erythema multiforme exudativum. During the course of the disease she developed disseminated varicella zoster and encephalitis. Positive polymerase chain reaction to varicella zoster in cerebrospinal fluid helped to differentiate her encephalitis from central nervous system symptoms due to microscopic angiitis and herpes simplex encephalitis. Combination of corticosteroid and acyclovir therapies for MPA and varicella zoster encephalitis under hemodialysis were successful. The diagnostic process and therapies to these complicated contexts were thought to be very important.
Authors	Junko Matsumoto, Ayako Nakajima, Akira Suwa, Yoshihiro Yasuki, Toshiyuki Yasui, Shinichi Inada
Journal	Ryumachi. [Rheumatism] (Ryumachi) Vol. 43 Issue 4 Pg. 703-9 (Oct 2003) ISSN: 0300-9157 [Print] Japan
PMID	14598666 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References	Antiviral Agents Acyclovir Methylprednisolone
Topics	Acute Kidney Injury (complications, therapy) Acyclovir (therapeutic use) Antiviral Agents (therapeutic use) Diagnosis, Differential Drug Therapy, Combination Encephalitis, Varicella Zoster (diagnosis, drug therapy, etiology) Female Herpes Zoster (diagnosis, drug therapy, etiology) Humans Immunocompromised Host Methylprednisolone (administration & dosage) Middle Aged Polyarteritis Nodosa (complications, diagnosis, drug therapy) Pulse Therapy, Drug Renal Dialysis Severity of Illness Index Treatment Outcome

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