Microtubule-associated protein 1B function during normal development, regeneration, and pathological conditions in the nervous system.

Abstract

Microtubule-associated protein 1B is the first MAP to be expressed during the development of the nervous system. Several different approaches have revealed that MAP1B function is associated with microtubule and actin microfilament polymerization and dynamics. In recent years, the generation of molecular models to inactivate MAP1B function in invertebrates and mammals has sparked some controversy about the real role of MAP1B. Despite discrepancies between some studies, it is clear that MAP1B plays a principal role in the development of the nervous system. In this article, we summarize the evidence for MAP1B function in a wide variety of cellular processes implicated in the proper construction of the nervous system. We also discuss the role of MAP1B in pathological processes.

• Authors: Christian Gonzalez-Billault, Eva Maria Jimenez-Mateos, Alfredo Caceres, Javier Diaz-Nido, Francisco Wandosell, Jesus Avila
• Journal: Journal of neurobiology (J Neurobiol) Vol. 58 Issue 1 Pg. 48-59 (Jan 2004) ISSN: 0022-3034 [Print] United States
• PMID: 14598369 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright 2003 Wiley Periodicals, Inc. J Neurobiol 58: 48-59, 2004

Chemical References

• Microtubule-Associated Proteins
• microtubule-associated protein 1B

Topics

• Animals
• Humans
• Microtubule-Associated Proteins (physiology)
• Nerve Regeneration (physiology)
• Nervous System (growth & development, physiopathology)
• Nervous System Diseases (physiopathology)
• Nervous System Physiological Phenomena