Central catecholamine, sympathetic nerve and vascular protein in the acute phase of two-kidney, one-clip renovascular hypertension in rats.

Abstract

Incorporation of 3H-proline into the non-collagenous protein in mesenteric arteries in two-kidney, one-clip hypertensive rats was greater than that in normotensive rats. Splanchnicotomy predominantly over the root of mesenteric arteries or intracranioventricular injection of 6-hydroxydopamine prevented the development of hypertension in 2K-1C rats concomitant with the reduction of incorporation of 3H-proline into the non-collagenous protein in mesenteric arteries. The content of norepinephrine in the hypothalamus in 2K-1C rats was lower than that in normotensive control rats. These findings indicate that increased non-collagenous protein synthesis in mesenteric arteries or low level of hypothalamic norepinephrine has facilitative effects on the development of 2K-1C hypertension.

• Authors: H Kaneko, T Nakada
• Journal: International urology and nephrology (Int Urol Nephrol) Vol. 24 Issue 5 Pg. 531-40 ( 1992) ISSN: 0301-1623 [Print] Netherlands
• PMID: 1459831 (Publication Type: Journal Article)

Chemical References

• Tritium
• Collagen
• Elastin
• Proline
• Norepinephrine

Topics

• Animals
• Aorta (metabolism)
• Collagen (metabolism)
• Elastin (metabolism)
• Hypertension, Renovascular (physiopathology)
• Hypothalamus (chemistry)
• Male
• Mesenteric Arteries (metabolism)
• Myocardium (metabolism)
• Norepinephrine (physiology)
• Proline (metabolism)
• Rats
• Rats, Wistar
• Sympathetic Nervous System (physiology)
• Tritium